The usual Leqvio (inclisiran) dosage for certain kinds of high cholesterol is 284 milligrams per 1.5 milliliters (mg/mL). Specific dosages may vary depending on factors like your individual symptoms and other medications you may be taking.
Leqvio comes as an injection given under your skin. The Leqvio injection dose is usually given on day 1, after that at 3 months, then every 6 months. Leqvio is used in adults to treat:
- heterozygous familial hypercholesterolemia
- atherosclerotic cardiovascular disease (heart disease related to high LDL cholesterol)
The active ingredient in Leqvio is inclisiran. Leqvio belongs to a group of drugs called small interfering RNA (siRNA).
This article describes the dosage of Leqvio, as well as its strength and how to take it. To learn more about Leqvio, including its side effects and uses, read this in-depth Leqvio article.
The following table highlights the basics of Leqvio’s dosage. All doses are listed in milligrams per milliliter (mg/mL).
| Leqvio form | Leqvio strength | Dosage | Frequency |
|---|---|---|---|
| single-dose prefilled syringe | 284 mg/1.5 mL | 284 mg injected once | day 1, at 3 months, then every 6 months |
Leqvio forms
Leqvio is a liquid solution that comes in a single-dose prefilled syringe. It’s given as an injection under your skin by a healthcare professional.
Leqvio strengths
Leqvio comes in one strength of 284 mg per 1.5 mL of liquid solution.
Leqvio is approved to treat the following conditions:
- high cholesterol in people with heterozygous familial hypercholesterolemia
- high cholesterol in people with atherosclerotic cardiovascular disease (heart disease related to high LDL cholesterol)
Always follow your doctor’s instructions. Notify them if you experience any of Leqvio’s side effects that may prevent you from receiving your medication.
Your doctor will likely also prescribe a statin drug and recommend a balanced diet during your treatment with Leqvio.
Dosage for heterozygous familial hypercholesterolemia
The recommended dosing schedule of Leqvio for heterozygous familial hypercholesterolemia is 284 mg injected once. You’ll receive a second Leqvio dose 3 months later, then every 6 months after that.
Dosage for heart disease related to high LDL cholesterol
The recommended dosing schedule of Leqvio for heart disease related to high LDL cholesterol is 284 mg injected once. You’ll receive a second Leqvio dose 3 months later, then every 6 months after that.
Leqvio comes in a single-dose, prefilled syringe. A healthcare professional will administer it to you in their office. They’ll inject it under the skin of your abdomen, upper arm, or thigh.
How long do you take Leqvio?
Leqvio is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for you, you’ll likely receive it long term.
The following are answers to some commonly asked questions about Leqvio’s dosage.
Is Leqvio’s dosage based on body weight?
No, Leqvio is not dosed by weight. The recommended dose is 284 mg for everyone, regardless of their weight.
Is there a Leqvio dosage for babies or older children?
No, Leqvio has not been approved by the Food and Drug Administration (FDA) for use in children. To learn more about treatment options for children with high cholesterol, talk with their doctor.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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