The usual Xcopri (cenobamate) dosage for focal onset seizures is 200 milligrams per day. Specific dosages may vary, depending on factors like your individual symptoms and other medications you may be taking. It’s important to take the Xcopri dosage your doctor prescribes.
Xcopri is used to treat focal onset seizures (also known as partial seizures) in adults. It belongs to a group of drugs called antiepileptic drugs.
Xcopri comes as a tablet that you swallow. Its active ingredient is cenobamate. (An active ingredient is what makes a medication work.)
This article describes the dosages of Xcopri, as well as its strengths and how to take it. To learn more about this drug, read this in-depth Xcopri article.
Your doctor will likely start by prescribing a low dosage of Xcopri and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
The following table highlights the basics of Xcopri’s dosage. All doses are in milligrams (mg).
Always take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown here.
| Weeks of treatment | Daily dosage |
|---|---|
| 1 and 2 | 12.5 mg |
| 3 and 4 | 25 mg |
| 5 and 6 | 50 mg |
| 7 and 8 | 100 mg |
| 9 and 10 | 150 mg |
| 11+ | 200 mg |
Xcopri form
Xcopri is available as a tablet that you swallow.
Xcopri strengths
Xcopri tablets come in the following strengths:
- 12.5 mg
- 25 mg
- 50 mg
- 100 mg
- 150 mg
- 200 mg
Xcopri is approved to treat focal onset seizures in adults. The typical Xcopri dosage for adults with this condition is 200 mg per day.
When you first start taking Xcopri, your doctor will recommend a dose titration. This means that your doctor will gradually increase your dose until you reach a maintenance dosage that’s right for you. This slow increase of your dose over time gives your body time to adjust to the medication and decreases the risk of Xcopri side effects.
For a table of the typical dosage increase after you begin taking Xcopri, see the “Xcopri dosage overview” section.
The recommended maintenance dosage is 200 mg taken once daily. But depending on how your body responds to the medication, your doctor may choose to continue increasing your dosage every 2 weeks by 50 mg per day. For example, your doctor might recommend that you take a dose of 250 mg per day for weeks 13 and 14 and a dose of 300 mg per day for weeks 15 and 16.
The maximum recommended dosage of Xcopri for focal onset seizures is 400 mg per day.
Always follow your doctor’s instructions. Notify them if you experience any side effects that may prevent you from taking your medication.
Your doctor or pharmacist will give you specific instructions for taking Xcopri.
Typically, you will swallow Xcopri tablets whole. But if you have difficulty swallowing pills, the drug’s prescribing information says you can also crush the tablets and then mix the powder with water before swallowing.
Xcopri can be taken at any time of day, with or without food.
Do not take more Xcopri than your doctor prescribes, as this can lead to serious side effects.
What to do in case you take too much Xcopri
Call your doctor right away if you think you’ve taken too much Xcopri. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Xcopri may cause dependence. With dependence, your body needs the drug to function as usual. If you suddenly stop taking Xcopri, you may experience withdrawal symptoms, such as:
- insomnia (trouble sleeping)
- decreased appetite
- depression
- tremor
- amnesia
In addition, suddenly stopping an antiepileptic drug, including Xcopri, increases your risk of seizures that do not stop (status epilepticus).
For these reasons, if you and your doctor decide that you should stop taking Xcopri, it’s safer to do so using a drug taper.
With a drug taper, your dosage is gradually decreased over a couple of weeks. If you develop any withdrawal symptoms, your dosage may be briefly increased again. Then the taper is started again at a slower pace. This will all be done under the supervision of your doctor.
The following are answers to some commonly asked questions about Xcopri’s dosage.
Is Xcopri used long term?
Yes, Xcopri is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.
What factors can affect my Xcopri dosage?
The dosage of Xcopri you’re prescribed may depend on several factors. These include:
- how your seizures respond to the medication
- whether you experience side effects
- other medical conditions you may have
If you have liver disease, the maximum recommended dosage of Xcopri is typically lowered to 200 mg once per day. The drug is generally not recommended for people who have severe liver disease or liver failure.
If you have kidney disease, your doctor may consider lowering your dosage. But if you have end stage kidney disease and are on dialysis, your doctor will likely recommend a different treatment for you.
What if I miss a dose?
If you miss a dose of Xcopri, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the dose.
You should not take two doses of Xcopri at once to make up for a missed dose. If you miss a dose and you aren’t sure whether you should take the missed dose, talk with your doctor or pharmacist.
If you need help remembering to take your dose of Xcopri on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
