The Zoryve (roflumilast) dosage used to treat plaque psoriasis, atopic dermatitis, and seborrheic dermatitis is a thin layer applied to the affected area once per day. But the strength of Zoryve you’re prescribed depends on the condition it’s used to treat.

The active ingredient in Zoryve is roflumilast. Zoryve belongs to a group of drugs called phosphodiesterase-4 (PDE-4) inhibitors. Zoryve is available as a topical cream and foam. (Topical drugs are applied to the skin.)

This article describes the dosage of Zoryve, as well as its strength and how to use it.

This section describes the usual dosages of Zoryve. Keep reading to learn more.

What is Zoryve’s form?

Zoryve comes as a topical cream and topical foam. With either form, you apply the drug to the affected area of skin.

What strength does Zoryve come in?

The form and strength of Zoryve you’re prescribed depends on the condition it’s being used to treat:

  • For plaque psoriasis: 0.3% cream
  • For mild to moderate atopic dermatitis (eczema): 0.15% cream
  • For seborrheic dermatitis: 0.3% foam

What’s the usual dosage of Zoryve?

The typical Zoryve dosage is a thin layer applied to the affected area once per day.

What’s the dosage of Zoryve for children?

Zoryve cream is used to help treat plaque psoriasis and atopic dermatitis in children ages 6 years and older. Zoryve foam is used to treat seborrheic dermatitis in children ages 9 years and older.

The dosage used in children is the same as the dosage for adults. The drug is applied as a thin layer to the affected area of skin once per day.

For more information about Zoryve’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Zoryve used long term?

Yes, Zoryve is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely use it long term.

Zoryve comes as a topical cream or foam that you apply to your skin. Wash your hands after using Zoryve, unless it’s being used to treat symptoms on your hands.

For information on the expiration, storage, and disposal of Zoryve, talk with your doctor or pharmacist.

If you miss a dose of Zoryve, apply the dose as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and apply your next dose at its usual time. If you’re not sure whether you should apply a missed dose, talk with your doctor or pharmacist.

Do not use more Zoryve than your doctor prescribes, as this can lead to harmful effects.

Call your doctor right away if you think you’ve used too much Zoryve. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

The following are answers to some commonly asked questions about Zoryve’s dosage.

Is Zoryve’s dosage similar to the dosages of Vtama or Humira?

Zoryve, tapinarof (Vtama) and adalimumab (Humira) are all used to treat plaque psoriasis. (Zoryve and Humira have other uses as well.) For plaque psoriasis, Zoryve and Vtama are both topical creams applied once per day. Humira, on the other hand, is a liquid solution that’s given as an injection under your skin every other week.

The strengths and dosages for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Zoryve to start working?

Zoryve starts to work after your first dose. If you’re prescribed the drug for plaque psoriasis or atopic dermatitis, you may notice your symptoms begin to ease as early as 2 weeks after starting treatment. But in some people, it may take up to 8 weeks before you see a significant difference in your symptoms.

For seborrheic dermatitis, you may see reduced symptoms within 4 weeks.

If you have other questions about what to expect from your Zoryve treatment, talk with your doctor.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.