Chronic types of leukemia tend to affect middle-aged to older adults, while acute versions mostly affect children and young adults. CML, CLL, and AML are fairly common types of leukemia affecting children and adults.

Leukemia refers to a type of cancer that impacts your blood cells and bone marrow.

The outlook for leukemia is difficult to predict due to the different types. Some leukemias are slow-growing (chronic), while others spread rapidly (acute). Each type has specific symptoms and treatment options.

CML starts in a type of white blood cell in your bone marrow called a granulocyte. It causes these cells to grow out of control.

Also called chronic granulocytic (or myeloid) leukemia, CML is partially associated with gene mutations called Philadelphia chromosomes.

This type of leukemia is most common in middle-aged adults and is rare in children. It’s estimated that 15% of leukemia cases in adults are CML.

As CML progresses, granulocytes grow rapidly and out of control in your bone marrow, crowding out healthy red and white blood cells.

Some of the initial symptoms include:

In some people, CML causes no symptoms at all.

Treatments

One promising area of treatment for CML involves targeted therapies that treat abnormal mutations from the Philadelphia chromosome. Researchers have found that targeted therapies can help people with CML survive closer to a “normal” life expectancy.

Vs. chronic myelomonocytic leukemia (CMML)

CMML is a type of leukemia that causes an abnormally high number of white cells — in this case, monocytes. Symptoms may include fatigue, bone pain, unresolved infections, easy bruising and bleeding, and unexpected weight loss.

Stem cell transplants and chemotherapy are common treatments for CMML.

CLL also occurs in the bone marrow, leading to the production of too many lymphocytes, another type of white blood cell.

Like CML, CLL tends to occur in middle-aged adults and is one of the most common types of adult-onset leukemia. CLL is also rare in children.

Unlike CML, CLL develops slowly. Some of the symptoms include:

You may not experience symptoms until CLL reaches a later phase.

Hairy cell leukemia (HCL)

HCL is a rare form of CLL that causes the same symptoms as CLL. It’s called a “hairy” cell because of the way the cancerous cells look under a microscope.

HCL is thought to occur mostly in older males, though the exact cause isn’t known. Unlike other types of leukemia, HCL isn’t defined by stages. It’s also more difficult to treat and may recur despite standard treatments.

Treatments

Targeted therapies are also used in early CLL cases. Research has shown that combination therapies may be more effective than using one targeted therapy at a time.

Another potential future treatment may include the use of chimeric antigen receptor (CAR) T-cell therapy. This type of immunotherapy alters healthy cells in a way they may more effectively attack cancerous ones.

Researchers are also investigating the possibility of additional targeted therapies to help treat HCL.

AML occurs when abnormal white blood cells called myeloblasts are present in the body. This type of cancer is also called acute myelogenous, granulocytic, nonlymphocytic, or myeloblastic leukemia.

The most common form of acute (fast-developing) leukemia among adults, AML is also the most critical because it progresses rapidly. Some adults previously treated for acute lymphocytic leukemia (ALL) as children may develop AML later in life.

Treatments

AML is most commonly treated with chemotherapy (with or without stem cell transplant) and radiation therapy. Various targeted therapies are relatively new in the treatment of AML, and different combinations are being researched further.

Also known as acute lymphoblastic leukemia (ALL), ALL is caused by the creation of too many lymphocytes. Unlike the chronic version of this cancer (CLL), ALL rapidly progresses if left untreated. However, ALL may respond quicker to treatment than AML.

Also, while CLL is more common in adults, ALL is more prevalent in children. However, certain risk factors may increase the risk of ALL in adults, such as being a white male over the age of 70.

Treatments

CAR T-cell therapy is currently used in children and young adults with ALL. As with CLL, research is ongoing into the possibility of using CAR T-cells for older adults with this type of cancer.

The exact type of treatment depends on the stage and type of leukemia you have, as well as your age.

Targeted therapies are used in earlier phases of this cancer, while surgeries and stem cell transplants are used when other treatment options haven’t worked. Stem cell transplants are also typically used in children.

Unlike other types of leukemia, treatment for CLL and HCL may include watchful waiting in the early stages due to their slower rates of progression.

Both ALL and AML progress rapidly. Early treatment is important to help prevent further spread.

A leukemia diagnosis can be challenging to process for both you and your loved ones, no matter which type you may have.

First, consider learning as much as you can about your cancer diagnosis. Talking with a doctor and asking them questions about treatment options and factors that affect your prognosis, may help you gain clarity.

Also, you may want to enlist the help of friends and loved ones for emotional support and assistance with daily tasks as you start cancer treatment.

For additional help, consider asking a doctor for local or virtual leukemia support groups. Such groups consist of individuals sharing similar experiences who may seek or offer advice while also helping you feel less alone.

Overall, the exact outlook for all types of leukemia depends on:

  • your age
  • the stage of progression of cancer cells
  • treatment response

AML and ALL progress quickly. It’s estimated that 1.5% of all people in the United States will develop leukemia in their lifetime. However, the overall mortality rate continues to decline, thanks to developing treatments.

Because everyone responds to leukemia medications differently, it’s important to continue talking with a doctor about all of your options.

The exact treatment and prognosis for leukemia depends greatly on the type due to each one’s differing effects on your blood cells. You may also need slower or more aggressive treatment depending on whether the case is chronic or acute.

Having friends and loved ones help you with anything you need, as well as a support group to share your experiences and learn from others, can help you prepare for and cope with the next steps in your journey.