Salmon sperm facials, also known as polydeoxyribonucleotide (PDRN) therapy, use purified DNA from salmon sperm to support skin regeneration.
Popularized in parts of Asia and gaining attention globally, this treatment aims to improve hydration, texture, and elasticity.
A salmon sperm facial begins with a thorough skin cleanse.
The solution may be applied topically — often combined with microneedling or laser to enhance absorption — or injected into the dermis, delivering the compound directly into deeper layers of the skin.
Each session typically lasts 20 to 30 minutes. You may experience mild discoloration or swelling after treatment, especially with microneedling or injections, but this usually subsides within a day or two.
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A 2024 review demonstrates benefits in skin elasticity and hydration, though outcomes vary between individuals.
Laboratory and small clinical studies support PDRN’s role in stimulating fibroblasts — the cells responsible for collagen — and promoting wound healing. Still, research is limited by small sample sizes and short durations.
Leading dermatologists caution that intradermal injections haven’t undergone thorough, large-scale clinical validation.
You might benefit from a salmon sperm facial if you’re:
- Looking to improve skin texture, tone, and hydration
- Interested in skin regeneration without fillers or Botox
- Recovering from other cosmetic procedures and want to enhance healing
Salmon sperm facials may lead to:
- Increased collagen and elastin production for firmer, plumper skin
- Reduced fine lines and improved elasticity with regular sessions
- Anti-inflammatory effects that may support post-treatment healing
- An overall “glowy” look that some users describe as immediate
Salmon sperm facials are generally well-tolerated. Still, potential side effects include:
- Temporary discoloration, swelling, or bruising
- Mild irritation or breakouts, especially with microneedling
- Allergic reactions
Be cautious if you have fish allergies or chronic inflammatory skin conditions such as rosacea or eczema. Some people have reported rashes and flare-ups post-treatment.
There’s a lack of long-term data for injectable PDRN in U.S. clinical settings. To minimize risks, choose a trained and licensed provider who uses sterile techniques and high quality products.
While more research is needed for long-term injectable use, topical application with microneedling is a safe and increasingly popular option.
Look for board certified dermatologists or licensed medical aestheticians experienced in regenerative skin care. Avoid unregulated clinics or providers offering injectable treatments without proper credentials.