Jaypirca (pirtobrutinib) is a prescription drug used to treat certain types of leukemia and lymphoma. Jaypirca can cause side effects that range from mild to serious. Examples include fatigue and diarrhea.

Specifically, Jaypirca is used in adults to treat:

The active ingredient in Jaypirca is pirtobrutinib. Jaypirca comes as an oral tablet.

Keep reading to learn about the common, mild, and serious side effects that Jaypirca can cause. For a detailed overview of this drug, check out this in-depth Jaypirca article.

Some people may experience mild to serious side effects during their Jaypirca treatment. Examples of the drug’s commonly reported side effects include:

The following sections include more side effects of Jaypirca. Each person’s experience with side effects may differ.

Mild side effects have been reported with Jaypirca. These include:

In most cases, these side effects should be temporary. And some may be managed easily. But if you have symptoms that are ongoing or bothersome, talk with your doctor or pharmacist. And do not stop Jaypirca treatment unless your doctor recommends it.

Jaypirca may cause mild side effects other than those listed above. See the drug’s prescribing information for details.

Serious side effects have been reported with Jaypirca. These include:

See the “Side effects explained” section to learn more about severe hemorrhage and heart rhythm problems.

If you develop serious side effects while taking Jaypirca, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911. Or call your local emergency number.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Jaypirca, visit MedWatch.

ALLERGIC REACTION

For some people, Jaypirca can cause an allergic reaction. This was a rare side effect reported in studies of the drug.

In general, symptoms of allergic reaction can be mild or serious.

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms. They also can determine whether you should continue Jaypirca treatment.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911. Or call your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

Your doctor can confirm whether you’ve had a serious allergic reaction to Jaypirca. If you have, your doctor may switch you to a different treatment.

Learn more about some of the side effects Jaypirca may cause.

Severe hemorrhage

Jaypirca can increase your risk of severe hemorrhage (blood loss). This is a serious side effect of the drug. Studies of Jaypirca reported gastrointestinal bleeding and bleeding in the brain. Rare cases of death from bleeding also were reported in studies of Jaypirca. Your risk may be higher if you already have a bleeding disorder such as hemophilia.

Some symptoms of bleeding may include:

What might help

Be sure to tell your doctor about any bleeding problems, liver problems, or kidney problems you have. These may increase your risk of severe hemorrhage. Also let your doctor know of any surgery or dental work you have planned. Finally, let them know of other medications you’re taking, as some may increase your risk of severe bleeding.

During Jaypirca treatment, call your doctor if you have any symptoms of bleeding listed above or if you have unusual bleeding. But if your symptoms feel life threatening, call 911 right away.

Heart rhythm problems

Heart rhythm problems were serious side effects reported in studies of Jaypirca. These include problems such as atrial flutter and atrial fibrillation.

Symptoms of heart rhythm problems may include:

What might help

Before starting Jaypirca treatment, be sure to tell your doctor if you have any heart problems or high blood pressure. They’ll discuss whether Jaypirca is safe for you to take.

If they do prescribe Jaypirca, they’ll monitor your blood pressure and heart activity. If your blood pressure becomes very high, they may stop the medication. If your heart problems seem to increase or worsen, they may refer you to a specialist and consider a safer treatment for you.

Keeping track of side effects

During your Jaypirca treatment, consider taking notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful when you first start a new drug or combination of treatments.

Your side effect notes can include things such as:

  • what dose of the drug you were taking when you had the side effect
  • how soon you had the side effect after starting that dose
  • what your symptoms were
  • how your symptoms affected your daily activities
  • what other medications you were taking
  • any other information you feel is important

Sharing notes with your doctor will help them learn more about how Jaypirca affects you. They can then use this information to adjust your treatment plan if needed.

Jaypirca can sometimes cause harmful effects in people who have certain conditions. This is known as a drug-condition interaction. Other factors also may affect whether Jaypirca is a good treatment option for you.

Talk with your doctor about your health history before you take Jaypirca. Be sure to tell them if any of the following factors apply to you:

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.