What to Know About Narcolepsy and Insomnia

How do insomnia and narcolepsy differ?

Both insomnia and narcolepsy have multiple causes. Research suggests that for some people, an imbalance in the production of hypocretin (or orexin), a brain chemical, may be an underlying cause for both.

Symptoms of narcolepsy vs. insomnia

Narcolepsy and insomnia have some symptoms that overlap, but they are significantly different in the way they present and have different causes.

Symptoms of narcolepsy

Narcolepsy symptoms include:

• Severe, extreme daytime sleepiness: This can occur even after a good night’s sleep. These episodes are sometimes referred to as sleep attacks. They differ from the tiredness and fatigue caused by insomnia.
• Cataplexy (in type 1): Cataplexy is a sudden loss of muscle tone that leads to bodily weakness and the loss of voluntary muscle control. Cataplexy occurs during periods of wakefulness. Intense emotions often trigger it.
• Sleep paralysis: Symptoms include temporary inability to speak or move when falling asleep or waking up. Episodes last for seconds or minutes.
• Hallucinations: Vivid, imaginary imagery that may be frightening can accompany sleep paralysis. These hallucinations can have an auditory component. They often occur at the beginning of the night or on waking up.
• Insomnia and fragmented sleep: Trouble falling and staying asleep is common in people with narcolepsy.

Symptoms of insomnia

The main symptoms of insomnia include:

• trouble falling asleep
• difficulty staying asleep
• waking up too early
• daytime fatigue and irritability
• trouble concentrating during the day
• problems with memory caused by lack of sleep

Causes of narcolepsy and insomnia

The main difference between narcolepsy and insomnia is their frequency of occurrence in the population. The symptoms and treatments of each also differ.

Causes of narcolepsy

Narcolepsy is a neurological disorder that alters the brain’s ability to control the sleep-wake cycle. People with narcolepsy may have insomnia as a symptom.

The two major types of narcolepsy are:

• Narcolepsy type 1. People with type 1 narcolepsy have low levels of orexin (hypocretin), a brain chemical that regulates wakefulness. Damage to the brain cells that produce this chemical may cause it. Narcolepsy type 1 is characterized by a symptom called cataplexy. This condition was formerly known as narcolepsy with cataplexy.
• Narcolepsy type 2. People with type 2 narcolepsy have normal levels of orexin. Cataplexy is not a symptom of type 2. This condition was formerly known as narcolepsy without cataplexy.

Causes of insomnia

Insomnia does not cause narcolepsy or narcolepsy symptoms.

A wide range of lifestyle factors and health conditions can cause insomnia, including:

• poor sleep hygiene and nighttime habits, such as late-night computer use
• emotions such as stress, worry, and anxiety
• alcohol or drug use
• nicotine use
• caffeine
• sleep apnea
• gastroesophageal reflux disease (GERD)
• restless leg syndrome
• medications, including some antidepressants and blood pressure medications
• Comorbid with medical and psychiatric conditions

Can you have narcolepsy and insomnia?

Narcolepsy and insomnia have both been linked to the same chemical in the brain: hypocretin (also called orexin).

Hypocretin is a naturally occurring chemical peptide that is mainly produced in the hypothalamus. This chemical plays a key role in the regulation of sleep and mood.

People with a diagnosis of narcolepsy type 1 have very low levels of hypocretin in their brains. On the opposite end of the spectrum, some people with insomnia may produce too much hypocretin.

Although people with narcolepsy produce too little hypocretin and are sleepy during the daytime, they often also have trouble staying asleep at night. They may experience fragmented sleep at night due to:

• insomnia
• sleep apnea
• vivid dreams
• acting out while dreaming

Are there any similar conditions to know about?

Narcolepsy is sometimes misdiagnosed as idiopathic hypersomnia. Hypersomnia is another condition that causes extreme daytime drowsiness and sleep attacks.

Narcolepsy may cause hypersomnia-like symptoms. But people with hypersomnia do not experience cataplexy. The cause of hypersomnia is not known.

Other conditions that can cause excessive sleepiness during the day include:

• sleep apnea
• depression
• intracranial brain tumors
• head trauma
• cerebral arteriosclerosis (hardening of the arteries in the brain)
• kidney failure
• low blood sugar
• hypothyroidism (underactive thyroid)

What are the treatment options?

You can manage the symptoms of these sleep conditions. Here are treatment options to consider.

Insomnia treatments

Insomnia often resolves when the underlying cause is reduced or removed.

If falling asleep is difficult, try altering your nighttime habits. Changes to make to your sleep routine can include:

• not drinking heavy amounts of alcohol, especially at night
• eliminating caffeine consumption in the evening or even late afternoon depending on your caffeine sensitivity
• not using your computer, phone, or any electronic device for several hours before bed
• wearing blue light glasses or adding a blue light filter to your computer screen
• lowering the temperature in your bedroom
• meditating or reading right before bed
• sleeping in total darkness

If changes to sleep habits don’t help, talk with a doctor about medications that may help.

Research published in 2021 indicates that medications that correct an orexin imbalance in people with insomnia may have benefits for managing this condition. These medications are referred to as dual orexin receptor antagonists (DORAs). Several are Food and Drug Administration (FDA) approved and available by prescription.

There are two different orexins:

• orexin A (hypocretin A)
• orexin B (hypocretin B)

In the brain, orexins interact with receptors that receive and respond to their chemical signals: orexin receptor type 1 and orexin receptor type 2. DORAs work by blocking one or both receptors from receiving these signals. This reduces the impact of orexin on the sleep-wake cycle.

You can also consider cognitive behavioral therapy for help with relaxation training. Cognitive behavioral therapy (CBT) has been found to have benefits for alleviating insomnia.

Narcolepsy treatments

If you think you have narcolepsy, a doctor or sleep disorder specialistt can help. They can help determine a diagnosis through tests for narcolepsy and for other potential causes. They’ll ask you about your symptoms and any family history of this condition.

Tests for narcolepsy include:

• Nocturnal polysomnogram. This test records your brain waves as well as nerve and muscle function during sleep.
• Multiple sleep latency test. This test measures the severity of your daytime sleepiness and rapidity of REM sleep.

Treatments for narcolepsy center on getting rid of or reducing symptoms. Treatment approaches include behavioral changes and using prescription medications.

The takeaway

Insomnia is a common sleep disorder that affects a large percentage of the population. It’s characterized by the inability to go to sleep or stay asleep. Narcolepsy, on the other hand, is a rare, chronic neurological sleep disorder that’s characterized by severe bouts of daytime drowsiness.

Narcolepsy and insomnia have some symptoms that overlap, but they’re significantly different in the way they present. They also have different causes and treatment options.

If you’re having trouble falling asleep or staying asleep at night, or find yourself having bouts of sleepiness during the day, even after a good night’s rest, contact a doctor to determine whether there’s an underlying cause and treatment options that work well for you.